Mitochondrial DNA variation analysis in historical provinces of Romania

Since the Middle Ages, Romanian population lived in three distinct provinces Wallachia, Moldavia and Transylvania until the 19th century. Over the centuries, their territories were repeatedly invaded by different peoples and subjected to external political influences resulting in demographic changes that could affected the genetic structure of populations. We performed mitochondrial DNA analysis in order to visualize the relationships between Romanian and other populations Europe based on HVSI and HVS II mtDNA sequence data using Sanger sequencing. We presented here a large scale mtDNA analysis of 612 Romanians from these historical provinces of Romania. Multidimensional scaling (MDS) plot was constructed from the pairwise Fst values. The results showed that present day Romanians in all provinces share their maternal ancestry with both eastern/central European and Balkan populations. The three populations of Romania analyzed here exhibit slightly different mtDNA lineage compositions, mainly consisting of the haplogroups H, U, J, T, K, N and W, with significant frequency differences corresponding for H, U and W haplogroups. H haplogroup accounts for 47% in Moldavia, 35 % in Wallachia and 33% in Transylvania. Overall, this study provides a first comprehensive analysis of mtDNA genome variation in Romania revealing the existence of different degrees of provincial differences of haplogroup frequencies.

Publication:European Journal of Human Genetics, Supplement 2, Abstracts (European Conference of Human Genetics 2
Published: 2014
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